| Host: | Mouse |
| Applications: | WB/CoIP |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Chromodomain-helicase-DNA-binding protein 4 is suitable for use in Western Blot and CoImmunoprecipitation research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 5F1-A11-C9 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2b |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000IP 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CHD4 |
| Gene ID: | 1108 |
| Uniprot ID: | CHD4_HUMAN |
| Specificity: | This antibody detects endogenous levels of CHD4 and does not cross-react with related proteins. |
| Immunogen: | Purified recombinant human CHD4 protein fragments expressed in E.coli. |
| Function | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination. Involved in neurogenesis. |
| Protein Name | Chromodomain-Helicase-Dna-Binding Protein 4Chd-4Atp-Dependent Helicase Chd4Mi-2 Autoantigen 218 Kda ProteinMi2-Beta |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-427389Reactome: R-HSA-6804758Reactome: R-HSA-73762Reactome: R-HSA-8943724Reactome: R-HSA-9031628Reactome: R-HSA-9679191Reactome: R-HSA-9843940Reactome: R-HSA-9844594Reactome: R-HSA-9845323 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeAssociates With Centrosomes In InterphaseLocalizes To Sites Of Dna Damage In A Manner Dependent On Zmynd8 And Znf687 |
| Alternative Antibody Names | Anti-Chromodomain-Helicase-Dna-Binding Protein 4 antibodyAnti-Chd-4 antibodyAnti-Atp-Dependent Helicase Chd4 antibodyAnti-Mi-2 Autoantigen 218 Kda Protein antibodyAnti-Mi2-Beta antibodyAnti-CHD4 antibody |
Information sourced from Uniprot.org
