Anti-CHD3 antibody (C-Term) [7F6-G2-E5] (STJ99071)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified recombinant human CHD3 (C-terminus) protein fragments expressed in E.coli.
General Information
| Short Description | Mouse monoclonal anti-Chromodomain-helicase-DNA-binding protein 3 (C-Term) for use in WB, ICC and IP in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IP |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 7F6-G2-E5 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000ICC 1:400 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CHD3 |
| Gene ID | 1107 |
| Uniprot ID | CHD3_HUMAN |
| Immunogen | Purified recombinant human CHD3 (C-terminus) protein fragments expressed in E.coli. |
| Immunogen Region | C-Term |
| Specificity | This antibody detects endogenous levels of CHD3 (C-terminus) and does not cross-react with related proteins. |
Additional Info
| Post Translational Modifications | Sumoylation at Lys-1971 results in dissociation from chromatin and suppression of transcriptional repression. |
| Function | ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Involved in transcriptional repression as part of the NuRD complex. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. |
| Protein Name | Chromodomain-Helicase-Dna-Binding Protein 3Chd-3Atp-Dependent Helicase Chd3Mi-2 Autoantigen 240 Kda ProteinMi2-AlphaZinc Finger HelicaseHzfh |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-427389Reactome: R-HSA-4551638Reactome: R-HSA-6804758Reactome: R-HSA-73762Reactome: R-HSA-8943724Reactome: R-HSA-9679191Reactome: R-HSA-9843940Reactome: R-HSA-9844594Reactome: R-HSA-9845323 |
| Cellular Localisation | NucleusPml BodyCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeAssociates With Centrosomes In Interphase And MitosisLocalizes To Sites Of Dna Damage |
| Alternative Antibody Names | Anti-Chromodomain-Helicase-Dna-Binding Protein 3 antibodyAnti-Chd-3 antibodyAnti-Atp-Dependent Helicase Chd3 antibodyAnti-Mi-2 Autoantigen 240 Kda Protein antibodyAnti-Mi2-Alpha antibodyAnti-Zinc Finger Helicase antibodyAnti-Hzfh antibodyAnti-CHD3 antibody |
Information sourced from Uniprot.org