| Host: | Rabbit |
| Applications: | IF/ICC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CHD2 |
| Gene ID: | 1106 |
| Uniprot ID: | CHD2_HUMAN |
| Immunogen Region: | 242-501 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 242-501 of human CHD2 (NP_001036037.1). |
| Immunogen Sequence: | SDDLIEMTGEGVDEQQDNSE TIEKVLDSRLGKKGATGAST TVYAIEANGDPSGDFDTEKD EGEIQYLIKWKGWSYIHSTW ESEESLQQQKVKGLKKLENF KKKEDEIKQWLGKVSPEDVE YFNCQQELASELNKQYQIVE RVIAVKTSKSTLGQTDFPAH SRKPAPSNEPEYLCKWMGLP YSECSWEDEALIGKKFQNCI DSFHSRNNSKTIPTRECKAL KQRPRFVALKKQPAYLGGE |
| Function | DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. |
| Protein Name | Chromodomain-Helicase-Dna-Binding Protein 2Chd-2Atp-Dependent Helicase Chd2 |
| Cellular Localisation | NucleusBinds To Myogenic Gene Promoters |
| Alternative Antibody Names | Anti-Chromodomain-Helicase-Dna-Binding Protein 2 antibodyAnti-Chd-2 antibodyAnti-Atp-Dependent Helicase Chd2 antibodyAnti-CHD2 antibody |
Information sourced from Uniprot.org