| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CFI (19-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CFI |
| Gene ID: |
3426 |
| Uniprot ID: |
CFAI_HUMAN |
| Immunogen Region: |
19-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 19-300 of human CFI (NP_000195.2). |
| Immunogen Sequence: |
KVTYTSQEDLVEKKCLAKKY THLSCDKVFCQPWQRCIEGT CVCKLPYQCPKNGTAVCATN RRSFPTYCQQKSLECLHPGT KFLNNGTCTAEGKFSVSLKH GNTDSEGIVEVKLVDQDKTM FICKSSWSMREANVACLDLG FQQGADTQRRFKLSDLSINS TECLHVHCRGLETSLAECTF TKRRTMGYQDFADVVCYTQK ADSPMDDFFQCVNGKYISQM KACDGINDCGDQSDELCCK |
| Tissue Specificity | Expressed in the liver by hepatocytes. Also present in other cells such as monocytes, fibroblasts or keratinocytes. |
| Function | Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization. |
| Protein Name | Complement Factor IC3b/C4b Inactivator Cleaved Into - Complement Factor I Heavy Chain - Complement Factor I Light Chain |
| Database Links | Reactome: R-HSA-977606 |
| Cellular Localisation | SecretedExtracellular Space |
| Alternative Antibody Names | Anti-Complement Factor I antibodyAnti-C3b/C4b Inactivator Cleaved Into - Complement Factor I Heavy Chain - Complement Factor I Light Chain antibodyAnti-CFI antibodyAnti-IF antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
