Anti-CFH antibody [SAA0527] (STJA0019363)

SKU:
STJA0019363
€473.13 - €2,040.63
Free Shipping
Processing The item has been added

Host: Mouse
Applications: ELISA/FC/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS
Short Description : Mouse monoclonal antibody anti-Complement Factor H is suitable for use in ELISA, Flow Cytometry and Western Blot research applications.
Clonality : Monoclonal
Clone ID : SAA0527
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Concentration: 1 mg/mL
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months
Gene Symbol: CFH
Gene ID: 3075
Uniprot ID: CFAH_HUMAN
Post Translational Modifications Sulfated on tyrosine residues. According to a report, Asn-217 is not glycosylated. Another study observed glycosylation at this position.
Function Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed. (Microbial infection) In the mosquito midgut, binds to the surface of parasite P.falciparum gametocytes and protects the parasite from alternative complement pathway-mediated elimination.
Protein Name Complement Factor H
H Factor 1
Database Links Reactome: R-HSA-977606
Cellular Localisation Secreted
(Microbial Infection) In The Mosquito Midgut
Localizes To P
Falciparum (Nf54 Strain) Macrogamete And Young Zygote Cell Membranes
Alternative Antibody Names Anti-Complement Factor H antibody
Anti-H Factor 1 antibody
Anti-CFH antibody
Anti-HF antibody
Anti-HF1 antibody
Anti-HF2 antibody

Information sourced from Uniprot.org