Anti-Recombinant-CFH antibody [RM1L71] (STJA0023659)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Complement Factor H for use in IF and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM1L71 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IF: 1:50-1:200 |
| Formulation | 0.01M PBS |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | CFH |
| Gene ID | 3075 |
| Uniprot ID | CFAH_HUMAN |
Additional Info
| Post Translational Modifications | Sulfated on tyrosine residues. According to a report, Asn-217 is not glycosylated. Another study observed glycosylation at this position. |
| Function | Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed. (Microbial infection) In the mosquito midgut, binds to the surface of parasite P.falciparum gametocytes and protects the parasite from alternative complement pathway-mediated elimination. |
| Protein Name | Complement Factor HH Factor 1 |
| Database Links | Reactome: R-HSA-977606 |
| Cellular Localisation | Secreted(Microbial Infection) In The Mosquito MidgutLocalizes To PFalciparum (Nf54 Strain) Macrogamete And Young Zygote Cell Membranes |
| Alternative Antibody Names | Anti-Complement Factor H antibodyAnti-H Factor 1 antibodyAnti-CFH antibodyAnti-HF antibodyAnti-HF1 antibodyAnti-HF2 antibody |
Information sourced from Uniprot.org