• Western blot analysis of various lysates using CES3 Rabbit polyclonal antibody (STJ116247) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 60s.

Anti-CES3 antibody (269-568) (STJ116247)

SKU:
STJ116247

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CES3 (269-568) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CES3
Gene ID: 23491
Uniprot ID: EST3_HUMAN
Immunogen Region: 269-568
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 269-568 of human CES3 (NP_001172106.1).
Immunogen Sequence: WPLAQKIANTLACSSSSPAE MVQCLQQKEGEELVLSKKLK NTIYPLTVDGTVFPKSPKEL LKEKPFHSVPFLMGVNNHEF SWLIPRGWGLLDTMEQMSRE DMLAISTPVLTSLDVPPEMM PTVIDEYLGSNSDAQAKCQA FQEFMGDVFINVPTVSFSRY LRDSGSPVFFYEFQHRPSSF AKIKPAWVKADHGAEGAFVF GGPFLMDESSRLEATEEEKQ LSLTMMAQWTHFARTGDPN
Tissue Specificity Expressed in liver, colon and small intestine.
Post Translational Modifications N-glycosylated.
Function Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-4-(1-piperidino)-1-piperidino-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.
Protein Name Carboxylesterase 3
Liver Carboxylesterase 31 Homolog
Database Links Reactome: R-HSA-211945
Reactome: R-HSA-8964038
Cellular Localisation Endoplasmic Reticulum Lumen
Alternative Antibody Names Anti-Carboxylesterase 3 antibody
Anti-Liver Carboxylesterase 31 Homolog antibody
Anti-CES3 antibody
Anti-UNQ869 antibody
Anti-PRO1887 antibody

Information sourced from Uniprot.org

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