| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
CENPT |
| Gene ID: |
80152 |
| Uniprot ID: |
CENPT_HUMAN |
| Immunogen Region: |
312-561 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 312-561 of human CENPT (NP_079358.3). |
| Immunogen Sequence: |
STSSGVSGEDEVEPLHDGVE EAEKKMEEEGVSVSEMEATG AQGPSRVEEAEGHTEVTEAE GSQGTAEADGPGASSGDEDA SGRAASPESASSTPESLQAR RHHQFLEPAPAPGAAVLSSE PAEPLLVRHPPRPRTTGPRP RQDPHKAGLSHYVKLFSFYA KMPMERKALEMVEKCLDKYF QHLCDDLEVFAAHAGRKTVK PEDLELLMRRQGLVTDQVSL HVLVERHLPLEYRQLLIPC |
| Post Translational Modifications | Dynamically phosphorylated at Ser-47 and probably also other sites during the cell cycle. Phosphorylated at Ser-47 during G2 phase, metaphase and anaphase, but not during telophase or G1 phase. |
| Function | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. |
| Protein Name | Centromere Protein TCenp-TInterphase Centromere Complex Protein 22 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-606279Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreConstitutively Localizes To Centromeres Throughout The Cell CycleAnd To Kinetochores During MitosisLocalizes To The Inner KinetochoreAnd May Connect It To The Outer Kinetochore Via Its N-Terminus |
| Alternative Antibody Names | Anti-Centromere Protein T antibodyAnti-Cenp-T antibodyAnti-Interphase Centromere Complex Protein 22 antibodyAnti-CENPT antibodyAnti-C16orf56 antibodyAnti-ICEN22 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
