| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Cell migration-inducing and hyaluronan-binding protein (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CEMIP |
| Gene ID: |
57214 |
| Uniprot ID: |
CEMIP_HUMAN |
| Immunogen Region: |
C-Term |
| Specificity: |
This antibody detects endogenous levels of K1199 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human C-ternal K1199 |
| Post Translational Modifications | N-glycosylated.glycosylation is not necessary for HA-binding. |
| Function | Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing. |
| Protein Name | Cell Migration-Inducing And Hyaluronan-Binding ProteinHyaluronan Binding Protein Involved In Hyaluronan Depolymerization |
| Database Links | Reactome: R-HSA-2142850 |
| Cellular Localisation | NucleusCytoplasmEndoplasmic ReticulumCell MembraneMembraneClathrin-Coated PitSecretedRetained In The Endoplasmic Reticulum (Er) In A Hspa5/Bip-Dependent MannerColocalized With Clathrin Heavy Chain/Cltc In Clathrin-Coated VesiclesStrongly Detected In The Cytoplasm Of Breast Carcinoma CellsWhereas Poorly Detected In Adjacent Normal Epithelial CellsStromal CellsOr Benign Breast TissuesLocalized In The Nucleus And Cytoplasm Of Colon Adenocarcinomas |
| Alternative Antibody Names | Anti-Cell Migration-Inducing And Hyaluronan-Binding Protein antibodyAnti-Hyaluronan Binding Protein Involved In Hyaluronan Depolymerization antibodyAnti-CEMIP antibodyAnti-HYBID antibodyAnti-KIAA1199 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
