| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDKN2C |
| Gene ID: | 1031 |
| Uniprot ID: | CDN2C_HUMAN |
| Immunogen Region: | 1-168 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-168 of human CDKN2C/p18-INK4C (P42773). |
| Immunogen Sequence: | MAEPWGNELASAAARGDLEQ LTSLLQNNVNVNAQNGFGRT ALQVMKLGNPEIARRLLLRG ANPDLKDRTGFAVIHDAARA GFLDTLQTLLEFQADVNIED NEGNLPLHLAAKEGHLRVVE FLVKHTASNVGHRNHKGDTA CDLARLYGRNEVVSLMQANG AGGATNLQ |
| Tissue Specificity | Highest levels found in skeletal muscle. Also found in pancreas and heart. |
| Function | Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. |
| Protein Name | Cyclin-Dependent Kinase 4 Inhibitor C Cyclin-Dependent Kinase 6 Inhibitor P18-Ink4c P18-Ink6 |
| Database Links | Reactome: R-HSA-2559580 Reactome: R-HSA-2559582 Reactome: R-HSA-2559585 Reactome: R-HSA-69231 |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 4 Inhibitor C antibody Anti-Cyclin-Dependent Kinase 6 Inhibitor antibody Anti-P18-Ink4c antibody Anti-P18-Ink6 antibody Anti-CDKN2C antibody Anti-CDKN6 antibody |
Information sourced from Uniprot.org