| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S7MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDK8 |
| Gene ID: | 1024 |
| Uniprot ID: | CDK8_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CDK8 (P49336). |
| Immunogen Sequence: | MDYDFKVKLSSERERVEDLF EYEGCKVGRGTYGHVYKAKR KDGKDDKDYALKQIEGTGIS MSACREIALLRELKHPNVIS LQKVFLSHADRKVWLLFDYA |
| Function | Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation. |
| Protein Name | Cyclin-Dependent Kinase 8Cell Division Protein Kinase 8Mediator Complex Subunit Cdk8Mediator Of Rna Polymerase Ii Transcription Subunit Cdk8Protein Kinase K35 |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-2122947Reactome: R-HSA-212436Reactome: R-HSA-2173796Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-381340Reactome: R-HSA-9833110 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 8 antibodyAnti-Cell Division Protein Kinase 8 antibodyAnti-Mediator Complex Subunit Cdk8 antibodyAnti-Mediator Of Rna Polymerase Ii Transcription Subunit Cdk8 antibodyAnti-Protein Kinase K35 antibodyAnti-CDK8 antibody |
Information sourced from Uniprot.org