| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CDK5RAP1 (1-350) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CDK5RAP1 |
| Gene ID: |
51654 |
| Uniprot ID: |
CK5P1_HUMAN |
| Immunogen Region: |
1-350 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human CDK5RAP1 (NP_057492.2). |
| Immunogen Sequence: |
MHPLQCVLQVQRSLGWGPLA SVSWLSLRMCRAHSSLSSTM CPSPERQEDGARKDFSSRLA AGPTFQHFLKSASAPQEKLS SEVEDPPPYLMMDELLGRQR KVYLETYGCQMNVNDTEIAW SILQKSGYLRTSNLQEADVI LLVTCSIREKAEQTIWNRLH QLKALKTRRPRSRVPLRIGI LGCMAERLKEEILNREKMVD ILAGPDAYRDLPRLLAVAES GQQAANVLLSLDETYADVM |
| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in neurons of central nervous tissue. Isoform 5: Mainly expressed in brain, placenta and testis. Isoform 6: High expression in placenta and lung. |
| Function | Methylthiotransferase that catalyzes the conversion of N6-(dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp). Essential for efficient and highly accurate protein translation by the ribosome. Specifically inhibits CDK5 activation by CDK5R1. Essential for efficient mitochondrial protein synthesis and respiratory chain.shows pathological consequences in mitochondrial disease. |
| Protein Name | Mitochondrial Trna Methylthiotransferase Cdk5rap1Cdk5 Activator-Binding Protein C42Cdk5 Regulatory Subunit-Associated Protein 1Mt-Trna-2-Methylthio-N6-Dimethylallyladenosine SynthaseMt-Trna-N6-(Dimethylallyladenosine(37 Methylthiotransferase |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Mitochondrial Trna Methylthiotransferase Cdk5rap1 antibodyAnti-Cdk5 Activator-Binding Protein C42 antibodyAnti-Cdk5 Regulatory Subunit-Associated Protein 1 antibodyAnti-Mt-Trna-2-Methylthio-N6-Dimethylallyladenosine Synthase antibodyAnti-Mt-Trna-N6-(Dimethylallyladenosine(37 Methylthiotransferase antibodyAnti-CDK5RAP1 antibodyAnti-C20orf34 antibodyAnti-CGI-05 antibodyAnti-HSPC167 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
