| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Cyclin-dependent kinase 2-associated protein 2 (51-100 aa) for use in IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDK2AP2 |
| Gene ID: | 10263 |
| Uniprot ID: | CDKA2_HUMAN |
| Immunogen Region: | 51-100 aa |
| Specificity: | DOC-1R Polyclonal Antibody detects endogenous levels of DOC-1R protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human CDKA2 at the amino acid range 51-100 |
| Post Translational Modifications | Phosphorylated by MAPK1 and CDK2. |
| Function | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation.represses CDK2 activation by inhibiting its interaction with cyclin E and A. Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes. |
| Protein Name | Cyclin-Dependent Kinase 2-Associated Protein 2Cdk2-Associated Protein 2Doc-1-Related ProteinDoc-1r |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusAccumulates In Immature Oocytes In The NucleusDuring The First Meiotic DivisionAccumulates In The Cytoplasm And Localizes In Dots In The Vicinity Of The Chromosomes In A Region Enriched In Microtubules |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 2-Associated Protein 2 antibodyAnti-Cdk2-Associated Protein 2 antibodyAnti-Doc-1-Related Protein antibodyAnti-Doc-1r antibodyAnti-CDK2AP2 antibodyAnti-DOC1R antibody |
Information sourced from Uniprot.org
