| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CDCA8 (1-124) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CDCA8 |
| Gene ID: |
55143 |
| Uniprot ID: |
BOREA_HUMAN |
| Immunogen Region: |
1-124 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-124 of human CDCA8 (NP_060571.1). |
| Immunogen Sequence: |
MAPRKGSSRVAKTNSLRRRK LASFLKDFDREVEIRIKQIE SDRQNLLKEVDNLYNIEILR LPKALREMNWLDYFALGGNK QALEEAATADLDITEINKLT AEAIQTPLKSAKTRKVIQVD EMIV |
| Post Translational Modifications | Phosphorylated by TTK, essentially at Thr-88, Thr94, Thr-169 and Thr-230. Phosphorylation (probably by CDK1) promotes targeting of the CPC to centromeric DNA. Sumoylated by UBE2I and RANBP2. Desumoylated by SENP3 through the removal of SUMO2 and SUMO3. |
| Function | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. |
| Protein Name | BorealinCell Division Cycle-Associated Protein 8Dasra-BHdasra-BPluripotent Embryonic Stem Cell-Related Gene 3 Protein |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-4615885Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusNucleolusCytoplasmCytoskeletonSpindleChromosomeCentromereLocalizes On Chromosome Arms And Inner Centromeres From Prophase Through Metaphase And Then Transferring To The Spindle Midzone And Midbody From Anaphase Through CytokinesisColocalizes With Senp3 In The Nucleolus In Interphase Cells |
| Alternative Antibody Names | Anti-Borealin antibodyAnti-Cell Division Cycle-Associated Protein 8 antibodyAnti-Dasra-B antibodyAnti-Hdasra-B antibodyAnti-Pluripotent Embryonic Stem Cell-Related Gene 3 Protein antibodyAnti-CDCA8 antibodyAnti-PESCRG3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
