| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDC45 |
| Gene ID: | 8318 |
| Uniprot ID: | CDC45_HUMAN |
| Immunogen Region: | 1-566 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-566 of human CDC45 (O75419). |
| Immunogen Sequence: | MFVSDFRKEFYEVVQSQRVL LFVASDVDALCACKILQALF QCDHVQYTLVPVSGWQELET AFLEHKEQFHYFILINCGAN VDLLDILQPDEDTIFFVCDT HRPVNVVNVYNDTQIKLLIK QDDDLEVPAYEDIFRDEEED EEHSGNDSDGSEPSEKRTRL EEEIVEQTMRRRQRREWEAR RRDILFDYEQYEYHGTSSAM VMFELAWMLSKDLNDMLWWA IVGLTDQWVQDKITQMKYV |
| Tissue Specificity | Widely expressed, highest levels are found in adult testis and thymus and in fetal liver. |
| Function | Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. |
| Protein Name | Cell Division Control Protein 45 Homolog Porc-Pi-1 |
| Database Links | Reactome: R-HSA-176187 Reactome: R-HSA-176974 Reactome: R-HSA-68962 Reactome: R-HSA-69205 |
| Cellular Localisation | Nucleus Chromosome Associates With Chromatin |
| Alternative Antibody Names | Anti-Cell Division Control Protein 45 Homolog antibody Anti-Porc-Pi-1 antibody Anti-CDC45 antibody Anti-CDC45L antibody Anti-CDC45L2 antibody Anti-UNQ374 antibody Anti-PRO710 antibody |
Information sourced from Uniprot.org