| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CDC45 (1-566) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CDC45 |
| Gene ID: |
8318 |
| Uniprot ID: |
CDC45_HUMAN |
| Immunogen Region: |
1-566 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-566 of human CDC45 (O75419). |
| Immunogen Sequence: |
MFVSDFRKEFYEVVQSQRVL LFVASDVDALCACKILQALF QCDHVQYTLVPVSGWQELET AFLEHKEQFHYFILINCGAN VDLLDILQPDEDTIFFVCDT HRPVNVVNVYNDTQIKLLIK QDDDLEVPAYEDIFRDEEED EEHSGNDSDGSEPSEKRTRL EEEIVEQTMRRRQRREWEAR RRDILFDYEQYEYHGTSSAM VMFELAWMLSKDLNDMLWWA IVGLTDQWVQDKITQMKYV |
| Tissue Specificity | Widely expressed, highest levels are found in adult testis and thymus and in fetal liver. |
| Function | Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. |
| Protein Name | Cell Division Control Protein 45 HomologPorc-Pi-1 |
| Database Links | Reactome: R-HSA-176187Reactome: R-HSA-176974Reactome: R-HSA-68962Reactome: R-HSA-69205 |
| Cellular Localisation | NucleusChromosomeAssociates With Chromatin |
| Alternative Antibody Names | Anti-Cell Division Control Protein 45 Homolog antibodyAnti-Porc-Pi-1 antibodyAnti-CDC45 antibodyAnti-CDC45L antibodyAnti-CDC45L2 antibodyAnti-UNQ374 antibodyAnti-PRO710 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
