| Host: | Rabbit |
| Applications: | IHC/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-CDC42 small effector protein 2 (3-53 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC-P 1:50-200 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDC42SE2 |
| Gene ID: | 56990 |
| Uniprot ID: | C42S2_HUMAN |
| Immunogen Region: | 3-53 aa |
| Specificity: | This antibody detects endogenous levels of C42S2 at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human C42S2 at the amino acid range 3-53 |
| Function | Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages. |
| Protein Name | Cdc42 Small Effector Protein 2 Small Effector Of Cdc42 Protein 2 |
| Database Links | Reactome: R-HSA-9013148 |
| Cellular Localisation | Cytoplasm Cytoskeleton Cell Membrane Lipid-Anchor Cell Projection Phagocytic Cup Recruited To The Activated Tcr Prior Actin Polymerization Localizes At The Phagocytic Cup Of Macrophages |
| Alternative Antibody Names | Anti-Cdc42 Small Effector Protein 2 antibody Anti-Small Effector Of Cdc42 Protein 2 antibody Anti-CDC42SE2 antibody Anti-SPEC2 antibody |
Information sourced from Uniprot.org
