| Function | Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Plays a role in the activation of monocytes and B-cells. Acts as an essential regulator of B-cell development by promoting interleukin-7 receptor/IL7R signaling. Promotes also in B-cells the BCR signaling by recruiting PKC to the plasma membrane in order to phosphorylate its substrates. Plays an essential role in lymphocyte homing to lymph nodes by stabilizing L-selectin/SELL cell surface expression. Mediates also metabolic and inflammatory functions in hepatocytes and adipose tissue by promoting TNF-alpha and LPS signaling independent of the immune compartment. Protects hematopoietic stem cell function in response to stress by facilitating DREAM complex activity through association with p130/RBL2 and its phosphatase PP2A. |
| Protein Name | Leukocyte Surface Antigen Cd53Cell Surface Glycoprotein Cd53Cd Antigen Cd53 |
| Database Links | Reactome: R-MMU-6798695 |
| Cellular Localisation | Cell MembraneCell JunctionMembraneMulti-Pass Membrane ProteinConcentrates In Localized Microdomains Along The Plasma Membrane At The Contact Sites Between Cells Of Fused Myotubes |
| Alternative Antibody Names | Anti-Leukocyte Surface Antigen Cd53 antibodyAnti-Cell Surface Glycoprotein Cd53 antibodyAnti-Cd Antigen Cd53 antibodyAnti-Cd53 antibody |
Information sourced from Uniprot.org
