Anti-CD45/PTPRC nanobody [2H5] (STJN000621)

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STJN000621
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Host: Alpaca
Applications: ELISA/SPR
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-CD45/PTPRC is suitable for use in ELISA and SPR research applications.
Clonality : Monoclonal
Clone ID : 2H5
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Protein A/G purified from cell culture supernatant.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: Ptprc
Gene ID: 19264
Uniprot ID: PTPRC_MOUSE
Function Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.
Protein Name Receptor-Type Tyrosine-Protein Phosphatase C
Leukocyte Common Antigen
L-Ca
Lymphocyte Antigen 5
Ly-5
T200
Cd Antigen Cd45
Database Links Reactome: R-MMU-202427
Reactome: -MMU-416700
Reactome: -MMU-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Membrane Raft
Synapse
Colocalized With Dpp4 In Membrane Rafts
Alternative Nanobody Names Anti-Receptor-Type Tyrosine-Protein Phosphatase C nanobody
Anti-Leukocyte Common Antigen nanobody
Anti-L-Ca nanobody
Anti-Lymphocyte Antigen 5 nanobody
Anti-Ly-5 nanobody
Anti-T200 nanobody
Anti-Cd Antigen Cd45 nanobody
Anti-Ptprc nanobody
Anti-Ly-5 nanobody

Information sourced from Uniprot.org

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