| Host: |
Rabbit |
| Applications: |
WB/FC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-CD3E+CD3G (1-207) is suitable for use in Western Blot and Flow Cytometry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S3942RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000FC 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunogen Region: |
1-207 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-207 (CD3E) & 1-182 (CD3G) of human CD3 epsilon&CD3 gamma Heterodimer. |
| Immunogen Sequence: |
MQSGTHWRVLGLCLLSVGVW GQDGNEEMGGITQTPYKVSI SGTTVILTCPQYPGSEILWQ HNDKNIGGDEDDKNIGSDED HLSLKEFSELEQSGYYVCYP RGSKPEDANFYLYLRARVCE NCMEMDVMSVATIVIVDICI TGGLLLLVYYWSKNRKAKAK PVTRGAGAGGRQRGQNKERP PPVPNPDYEPIRKGQRDLYS GLNQRRI (CD3E) &MEQGKG LAVLILAIILLQGTLAQ |
| Background | The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma,-delta and-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon,-delta and-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
