| Host: | Mouse |
| Applications: | IHC/IF/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (200-300 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | ABT298 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2bk |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: | IHC-P 1:100-500 WB 1:200-1000 IF 1:100-500 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CD38 |
| Gene ID: | 952 |
| Uniprot ID: | CD38_HUMAN |
| Immunogen Region: | 200-300 aa |
| Specificity: | The antibody can specifically recognize human CD38 protein. |
| Immunogen: | Synthesized peptide derived from the human CD38 at the amino acid range 200-300 |
| Function | Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion. Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+). Has cADPR hydrolase activity. |
| Protein Name | Adp-Ribosyl Cyclase/Cyclic Adp-Ribose Hydrolase 1 2'-Phospho-Adp-Ribosyl Cyclase 2'-Phospho-Adp-Ribosyl Cyclase/2'-Phospho-Cyclic-Adp-Ribose Transferase 2'-Phospho-Cyclic-Adp-Ribose Transferase Adp-Ribosyl Cyclase 1 Adprc 1 Cyclic Adp-Ribose Hydrolase 1 Cadpr Hydrolase 1 T10 Cd Antigen Cd38 |
| Database Links | Reactome: R-HSA-196807 |
| Cellular Localisation | Cell Surface Membrane Single-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Adp-Ribosyl Cyclase/Cyclic Adp-Ribose Hydrolase 1 antibody Anti-2'-Phospho-Adp-Ribosyl Cyclase antibody Anti-2'-Phospho-Adp-Ribosyl Cyclase/2'-Phospho-Cyclic-Adp-Ribose Transferase antibody Anti-2'-Phospho-Cyclic-Adp-Ribose Transferase antibody Anti-Adp-Ribosyl Cyclase 1 antibody Anti-Adprc 1 antibody Anti-Cyclic Adp-Ribose Hydrolase 1 antibody Anti-Cadpr Hydrolase 1 antibody Anti-T10 antibody Anti-Cd Antigen Cd38 antibody Anti-CD38 antibody |
Information sourced from Uniprot.org