Anti-CD279/PDCD1/PD1 nanobody [SAA1280] (STJN000275)

Anti-CD279/PDCD1/PD1 nanobody [SAA1280] (STJN000275)

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STJN000275
$510.98 - $2,203.88
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Covered by St John's Laboratory Guarantee

Host: Alpaca
Applications: ELISA/FC/SPR
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Programmed Cell Death Protein 1 is suitable for use in ELISA, Flow Cytometry and SPR research applications.
Clonality : Monoclonal
Clone ID : SAA1280
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: PDCD1
Gene ID: 5133
Uniprot ID: PDCD1_HUMAN
Function Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta. The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy.
Protein Name Programmed Cell Death Protein 1
Protein Pd-1
Hpd-1
Cd Antigen Cd279
Database Links Reactome: R-HSA-389948
Reactome: R-HSA-9679191
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Nanobody Names Anti-Programmed Cell Death Protein 1 nanobody
Anti-Protein Pd-1 nanobody
Anti-Hpd-1 nanobody
Anti-Cd Antigen Cd279 nanobody
Anti-PDCD1 nanobody
Anti-PD1 nanobody

Information sourced from Uniprot.org

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