| Post Translational Modifications | (Microbial infection) Glycosylated on Arg residue by S.typhimurium protein Ssek3. |
| Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 10bDeath Receptor 5Tnf-Related Apoptosis-Inducing Ligand Receptor 2Trail Receptor 2Trail-R2Cd Antigen Cd262 |
| Database Links | Reactome: R-HSA-140534Reactome: R-HSA-202733Reactome: R-HSA-3371378Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-6803211Reactome: R-HSA-69416Reactome: R-HSA-75158 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 10b antibodyAnti-Death Receptor 5 antibodyAnti-Tnf-Related Apoptosis-Inducing Ligand Receptor 2 antibodyAnti-Trail Receptor 2 antibodyAnti-Trail-R2 antibodyAnti-Cd Antigen Cd262 antibodyAnti-TNFRSF10B antibodyAnti-DR5 antibodyAnti-KILLER antibodyAnti-TRAILR2 antibodyAnti-TRICK2 antibodyAnti-ZTNFR9 antibodyAnti-UNQ160 antibodyAnti-PRO186 antibody |
Information sourced from Uniprot.org
![Anti-CD262/TNFRSF10B/TRAIL-R2/DR5 antibody [SAA2021] (STJA0020568)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/189284/412633/STJA0020568-SDS-PAGE-1__61900.1749229592.jpg?c=1 "Anti-CD262/TNFRSF10B/TRAIL-R2/DR5 antibody [SAA2021] (STJA0020568)")