Anti-CD262/DR5/TRAILR2 antibody [SRM13369] (STJ11108099)

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STJ11108099
€142.20 - €625.80
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Short Description :Rabbit monoclonal Tumor Necrosis Factor Receptor Superfamily Member 10b antibody for use in FC and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:FC/ELISA
Host:Rabbit
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :SRM13369
Isotype:IgG
Conjugation:Unconjugated
Concentration:Lot specific
Purification:Affinity purification
Dilution Range:FC, 1:100-1:500
ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation:PBS containing 50% Glycerol and 0.05% BSA, preserved with proclin300 or Sodium Azide (as specified on the Certificate of Analysis) , pH 7.3.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:TNFRSF10B
Gene ID:8795
Uniprot ID:TR10B_HUMAN
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Immunogen Sequence:Human
Post Translational Modifications (Microbial infection) Glycosylated on Arg residue by S.typhimurium protein Ssek3.
Function Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 10b
Death Receptor 5
Tnf-Related Apoptosis-Inducing Ligand Receptor 2
Trail Receptor 2
Trail-R2
Cd Antigen Cd262
Database Links Reactome: R-HSA-140534
Reactome: R-HSA-202733
Reactome: R-HSA-3371378
Reactome: R-HSA-5213460
Reactome: R-HSA-5218900
Reactome: R-HSA-6803211
Reactome: R-HSA-69416
Reactome: R-HSA-75158
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Tumor Necrosis Factor Receptor Superfamily Member 10b antibody
Anti-Death Receptor 5 antibody
Anti-Tnf-Related Apoptosis-Inducing Ligand Receptor 2 antibody
Anti-Trail Receptor 2 antibody
Anti-Trail-R2 antibody
Anti-Cd Antigen Cd262 antibody
Anti-TNFRSF10B antibody
Anti-DR5 antibody
Anti-KILLER antibody
Anti-TRAILR2 antibody
Anti-TRICK2 antibody
Anti-ZTNFR9 antibody
Anti-UNQ160 antibody
Anti-PRO186 antibody

Information sourced from Uniprot.org

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