| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CD24 |
| Gene ID: | 100133941 |
| Uniprot ID: | CD24_HUMAN |
| Immunogen Region: | 1-80 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human CD24 (NP_037362.1). |
| Immunogen Sequence: | MGRAMVARLGLGLLLLALLL PTQIYSSETTTGTSSNSSQS TSNSGLAPNPTNATTKAAGG ALQSTASLFVVSLSLLHLYS |
| Tissue Specificity | B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells. |
| Post Translational Modifications | Extensively O-glycosylated. |
| Function | May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity. |
| Protein Name | Signal Transducer Cd24 Small Cell Lung Carcinoma Cluster 4 Antigen Cd Antigen Cd24 |
| Database Links | Reactome: R-HSA-373760 |
| Cellular Localisation | Cell Membrane Lipid-Anchor Gpi-Anchor |
| Alternative Antibody Names | Anti-Signal Transducer Cd24 antibody Anti-Small Cell Lung Carcinoma Cluster 4 Antigen antibody Anti-Cd Antigen Cd24 antibody Anti-CD24 antibody Anti-CD24A antibody |
Information sourced from Uniprot.org