| Post Translational Modifications | Glycosylated. Contains high mannose- and complex-type oligosaccharides. Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms. The soluble form is produced by a proteolytic cleavage. |
| Function | Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. |
| Protein Name | Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-ACd16a AntigenFc-Gamma Riii-AlphaFc-Gamma RiiiFc-Gamma RiiiaFcriiiFcriiiaFcr-10Igg Fc Receptor Iii-2Cd Antigen Cd16a |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-2029481Reactome: R-HSA-2029482Reactome: R-HSA-2029485Reactome: R-HSA-9664323Reactome: R-HSA-9664422 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinSecretedExists Also As A Soluble Receptor |
| Alternative Antibody Names | Anti-Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-A antibodyAnti-Cd16a Antigen antibodyAnti-Fc-Gamma Riii-Alpha antibodyAnti-Fc-Gamma Riii antibodyAnti-Fc-Gamma Riiia antibodyAnti-Fcriii antibodyAnti-Fcriiia antibodyAnti-Fcr-10 antibodyAnti-Igg Fc Receptor Iii-2 antibodyAnti-Cd Antigen Cd16a antibodyAnti-FCGR3A antibodyAnti-CD16A antibodyAnti-FCG3 antibodyAnti-FCGR3 antibodyAnti-IGFR3 antibody |
Information sourced from Uniprot.org
