| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CCS |
| Gene ID: | 9973 |
| Uniprot ID: | CCS_HUMAN |
| Immunogen Region: | 1-274 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human CCS (NP_005116.1). |
| Immunogen Sequence: | MASDSGNQGTLCTLEFAVQM TCQSCVDAVRKSLQGVAGVQ DVEVHLEDQMVLVHTTLPSQ EVQALLEGTGRQAVLKGMGS GQLQNLGAAVAILGGPGTVQ GVVRFLQLTPERCLIEGTID GLEPGLHGLHVHQYGDLTNN CNSCGNHFNPDGASHGGPQD SDRHRGDLGNVRADADGRAI FRMEDEQLKVWDVIGRSLII DEGEDDLGRGGHPLSKITGN SGERLACGIIARSAGLFQN |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Ubiquitinion by XIAP/BIRC4 leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. XIAP/BIRC4 preferentially ubiquitinates at Lys-241. |
| Function | Delivers copper to copper zinc superoxide dismutase (SOD1). |
| Protein Name | Copper Chaperone For Superoxide DismutaseSuperoxide Dismutase Copper Chaperone |
| Database Links | Reactome: R-HSA-3299685 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Copper Chaperone For Superoxide Dismutase antibodyAnti-Superoxide Dismutase Copper Chaperone antibodyAnti-CCS antibody |
Information sourced from Uniprot.org