| Short Description : | Rabbit polyclonal anti-Cyclin E1 (N-Term) for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | Antigen Affinity Purified |
| Dilution Range: | WB 1:500-1:1000 |
| Formulation: | PBS + 0.02% NaN3 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CCNE1 |
| Gene ID: | 898 |
| Uniprot ID: | CCNE1_HUMAN |
| Immunogen: | Synthetic peptide corresponding to amino acids from the N-terminal region of human Cyclin E1 protein |
| Immunogen Region: | N-Term |
| Specificity: | Reacts with the N-terminal region of human Cyclin E1 protein |
| Post Translational Modifications | Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7. Ubiquitinated by UHRF2.appears to occur independently of phosphorylation. |
| Function | Essential for the control of the cell cycle at the G1/S (start) transition. |
| Protein Name | G1/S-Specific Cyclin-E1 |
| Database Links | Reactome: R-HSA-1538133Reactome: R-HSA-187577Reactome: R-HSA-2559586Reactome: R-HSA-390471Reactome: R-HSA-6804116Reactome: R-HSA-69017Reactome: R-HSA-69200Reactome: R-HSA-69202Reactome: R-HSA-69205Reactome: R-HSA-69231Reactome: R-HSA-69563Reactome: R-HSA-8849470Reactome: R-HSA-9661069Reactome: R-HSA-9706019 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-G1/S-Specific Cyclin-E1 antibodyAnti-CCNE1 antibodyAnti-CCNE antibody |
Information sourced from Uniprot.org
