Anti-CCNE1 antibody (300-400) (STJ116441)

SKU:
STJ116441
€132.60 - €606.60
Free Shipping
Processing The item has been added

Short Description :Rabbit polyclonal CCNE1 (300-400) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB/ELISA
Host:Rabbit
Reactivity:Mouse/Rat
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Concentration:Lot specific
Purification:Affinity purification
Dilution Range:WB:1:500-1:1000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation:PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:CCNE1
Gene ID:898
Uniprot ID:CCNE1_HUMAN
Immunogen Region:300-400
Immunogen Sequence:AASALYHFSSSELMQKVSGY QWCDIENCVKWMVPFAMVIR ETGSSKLKHFRGVADEDAHN IQTHRDSLDLLDKARAKKAM LSEQNRASPLPSGLLTPPQS G
Specificity:A synthetic peptide corresponding to a sequence within amino acids 300-400 of human Cyclin E1 (NP_001229.1).
Tissue Specificity Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
Post Translational Modifications Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7. Ubiquitinated by UHRF2.appears to occur independently of phosphorylation.
Function Essential for the control of the cell cycle at the G1/S (start) transition.
Protein Name G1/S-Specific Cyclin-E1
Database Links Reactome: R-HSA-1538133
Reactome: R-HSA-187577
Reactome: R-HSA-2559586
Reactome: R-HSA-390471
Reactome: R-HSA-6804116
Reactome: R-HSA-69017
Reactome: R-HSA-69200
Reactome: R-HSA-69202
Reactome: R-HSA-69205
Reactome: R-HSA-69231
Reactome: R-HSA-69563
Reactome: R-HSA-8849470
Reactome: R-HSA-9661069
Reactome: R-HSA-9706019
Cellular Localisation Nucleus
Alternative Antibody Names Anti-G1/S-Specific Cyclin-E1 antibody
Anti-CCNE1 antibody
Anti-CCNE antibody

Information sourced from Uniprot.org