| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CCNB1IP1 (1-50) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CCNB1IP1 |
| Gene ID: |
57820 |
| Uniprot ID: |
CIP1_HUMAN |
| Immunogen Region: |
1-50 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-50 of human CCNB1IP1 (NP_878269.1). |
| Immunogen Sequence: |
MSLCEDMLLCNYRKCRIKLS GYAWVTACSHIFCDQHGSGE FSRSPAICPA |
| Tissue Specificity | Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung. |
| Post Translational Modifications | Ubiquitinated.autoubiquitinated. Phosphorylated by CDK1 on serine or threonine residues (in vitro). |
| Function | Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over. Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. |
| Protein Name | E3 Ubiquitin-Protein Ligase Ccnb1ip1Cyclin-B1-Interacting Protein 1Human Enhancer Of Invasion 10Ring-Type E3 Ubiquitin Transferase Ccnb1ip1 |
| Cellular Localisation | NucleusChromosomeAssociates To The Synaptonemal Complex |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Ccnb1ip1 antibodyAnti-Cyclin-B1-Interacting Protein 1 antibodyAnti-Human Enhancer Of Invasion 10 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Ccnb1ip1 antibodyAnti-CCNB1IP1 antibodyAnti-C14orf18 antibodyAnti-HEI10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
