| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-CCL21 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:1000.WB: Approx 16kDa band observed in Human Lymph Node lysates (calculated MW of 14.6kDa according to NP_002980.1). Recommended concentration: 0.03-0.1µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | CCL21 |
| Gene ID: | 6366 |
| Uniprot ID: | CCL21_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_002980.1 |
| Specificity: | This antibody may cross-react with mouse CCL21 (GeneID: 18829) and rat CCL21 (GeneID: 298006). |
| Immunogen Sequence: | QGCRKDRGASKTG |
| Function | Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. |
| Protein Name | C-C Motif Chemokine 216ckineBeta-Chemokine Exodus-2Secondary Lymphoid-Tissue ChemokineSlcSmall-Inducible Cytokine A21 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-C-C Motif Chemokine 21 antibodyAnti-6ckine antibodyAnti-Beta-Chemokine Exodus-2 antibodyAnti-Secondary Lymphoid-Tissue Chemokine antibodyAnti-Slc antibodyAnti-Small-Inducible Cytokine A21 antibodyAnti-CCL21 antibodyAnti-SCYA21 antibodyAnti-UNQ784 antibodyAnti-PRO1600 antibody |
Information sourced from Uniprot.org