| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-C-C Motif Chemokine 17 (450-550) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CCL17 |
| Gene ID: |
6361 |
| Uniprot ID: |
CCL17_HUMAN |
| Immunogen Region: |
450-550 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 450-550 of human AAK1 (NP_055726.4). |
| Immunogen Sequence: |
AQGLPAQAQATPQHQQQLFL KQQQQQQQPPPAQQQPAGTF YQQQQAQTQQFQAVHPATQK PAIAQFPVVSQGGSQQQLMQ NFYQQQQQQQQQQQQQQLAT A |
| Tissue Specificity | Constitutively expressed in thymus. Detected at lower levels in the lung, colon and small intestine. Expressed in stimulated peripheral blood mononuclear cells, but not in resting cells. |
| Function | Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes. Acts by binding to CCR4 at T-cell surface. Mediates GM-CSF/CSF2-driven pain and inflammation. In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation. Plays a role in wound healing, mainly by inducing fibroblast migration into the wound. |
| Protein Name | C-C Motif Chemokine 17Cc Chemokine TarcSmall-Inducible Cytokine A17Thymus And Activation-Regulated Chemokine |
| Database Links | Reactome: R-HSA-380108 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-C-C Motif Chemokine 17 antibodyAnti-Cc Chemokine Tarc antibodyAnti-Small-Inducible Cytokine A17 antibodyAnti-Thymus And Activation-Regulated Chemokine antibodyAnti-CCL17 antibodyAnti-SCYA17 antibodyAnti-TARC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
