| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | CCDC3 |
| Gene ID: | 83643 |
| Uniprot ID: | CCDC3_HUMAN |
| Immunogen Region: | 141-270 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 141-270 of human CCDC3 (NP_113643.1). |
| Immunogen Sequence: | DAIFPDTQENRRMFSSLFQF SNCSQGQQLATFSSDWEIQE DSRLMCSSVQKALFEEEDHV KKLQQKVATLEKRNRQLRER VKKVKRSLRQARKKGRHLEL ANQKLSEKLAAGALPHINAR GPVRPPYLRG |
| Tissue Specificity | Expressed in umbilical vein endothelial cells (HUVEC), and at lower levels in aortic smooth muscle cells (HASMC). |
| Function | Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs. Positively regulates lipid accumulation in adipose cells. |
| Protein Name | Coiled-Coil Domain-Containing Protein 3Fat/Vessel-Derived Secretory ProteinFavine |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Coiled-Coil Domain-Containing Protein 3 antibodyAnti-Fat/Vessel-Derived Secretory Protein antibodyAnti-Favine antibodyAnti-CCDC3 antibody |
Information sourced from Uniprot.org
