| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-HP1 gamma (1-100) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S1MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CBX3 |
| Gene ID: |
11335 |
| Uniprot ID: |
CBX3_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HP1 gamma/CBX3 (NP_057671.2). |
| Immunogen Sequence: |
MASNKTTLQKMGKKQNGKSK KVEEAEPEEFVVEKVLDRRV VNGKVEYFLKWKGFTDADNT WEPEENLDCPELIEAFLNSQ KAGKEKDGTKRKSLSDSESD |
| Post Translational Modifications | Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis. |
| Function | Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs). |
| Protein Name | Chromobox Protein Homolog 3HechHeterochromatin Protein 1 Homolog GammaHp1 GammaModifier 2 Protein |
| Database Links | Reactome: R-HSA-427389Reactome: R-HSA-73772Reactome: R-HSA-8953750 |
| Cellular Localisation | NucleusAssociates With Euchromatin And Is Largely Excluded From Constitutive HeterochromatinMay Be Associated With Microtubules And Mitotic Poles During Mitosis (Potential) |
| Alternative Antibody Names | Anti-Chromobox Protein Homolog 3 antibodyAnti-Hech antibodyAnti-Heterochromatin Protein 1 Homolog Gamma antibodyAnti-Hp1 Gamma antibodyAnti-Modifier 2 Protein antibodyAnti-CBX3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunoprecipitation analysis of 300 Mu g extracts from Jurkat cells using 3 Mu g [KD Validated] DNMT1 Rabbit monoclonal antibody (STJ11101761). Western blot was performed from the immunoprecipitate using DNMT1 (STJ11101761) at a dilution of 1:1000.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/90676/360693/STJ11101761_1__79926.1713125393.jpg?c=1 "Immunoprecipitation analysis of 300 Mu g extracts from Jurkat cells using 3 Mu g [KD Validated] DNMT1 Rabbit monoclonal antibody (STJ11101761). Western blot was performed from the immunoprecipitate using DNMT1 (STJ11101761) at a dilution of 1:1000.")
