• Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using CBR1 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of lysates from HeLa cells, using CBR1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of 293T HELA using Carbonyl Reductase 1 Polyclonal Antibody. Antibody was diluted at 1:1000

Anti-CBR1 antibody (181-230 aa) (STJ91997)

SKU:
STJ91997

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Carbonyl reductase 1+ CBR1 9-reductase (181-230 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CBR1
Gene ID: 873
Uniprot ID: CBR1_HUMAN
Immunogen Region: 181-230 aa
Specificity: Carbonyl Reductase 1 Polyclonal Antibody detects endogenous levels of Carbonyl Reductase 1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human CBR1 at the amino acid range 181-230
Function NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue.
Protein Name Carbonyl Reductase Nadph 1
15-Hydroxyprostaglandin Dehydrogenase Nadp(+
20-Beta-Hydroxysteroid Dehydrogenase
Alcohol Dehydrogenase Nad(P+ Cbr1
Nadph-Dependent Carbonyl Reductase 1
Prostaglandin 9-Ketoreductase
Pg-9-Kr
Prostaglandin-E(2 9-Reductase
Short Chain Dehydrogenase/Reductase Family 21c Member 1
Database Links Reactome: R-HSA-2162123
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Carbonyl Reductase Nadph 1 antibody
Anti-15-Hydroxyprostaglandin Dehydrogenase Nadp(+ antibody
Anti-20-Beta-Hydroxysteroid Dehydrogenase antibody
Anti-Alcohol Dehydrogenase Nad(P+ Cbr1 antibody
Anti-Nadph-Dependent Carbonyl Reductase 1 antibody
Anti-Prostaglandin 9-Ketoreductase antibody
Anti-Pg-9-Kr antibody
Anti-Prostaglandin-E(2 9-Reductase antibody
Anti-Short Chain Dehydrogenase/Reductase Family 21c Member 1 antibody
Anti-CBR1 antibody
Anti-CBR antibody
Anti-CRN antibody
Anti-SDR21C1 antibody

Information sourced from Uniprot.org

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