| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Calcium Sensing Receptor (N-Term) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
| Purification: |
Antigen affinity purified from pooled serum |
| Dilution Range: |
WB 1:1000IHCICCIP |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Casr |
| Gene ID: |
24247 |
| Uniprot ID: |
CASR_RAT |
| Immunogen Region: |
N-Term |
| Immunogen: |
Synthetic peptide from the N-terminus region of the rat calcium sensing receptor. |
| Function | G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation. |
| Protein Name | Extracellular Calcium-Sensing ReceptorCasrParathyroid Cell Calcium-Sensing ReceptorPcar1Rakcar |
| Database Links | Reactome: R-RNO-416476Reactome: -RNO-418594Reactome: -RNO-420499 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Extracellular Calcium-Sensing Receptor antibodyAnti-Casr antibodyAnti-Parathyroid Cell Calcium-Sensing Receptor antibodyAnti-Pcar1 antibodyAnti-Rakcar antibodyAnti-Casr antibodyAnti-Gprc2a antibodyAnti-Pcar1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
