Western blot of lysed HFF cells that were serum starved for 24 hours and then refed for 30 minutes showing specific immunolabeling of the ~130-260 kDa CaSR protein.

Anti-CaSR antibody (N-Term) (STJA0003868)

SKU:
STJA0003868-100
€568.13
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Calcium Sensing Receptor (N-Term) is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: Antigen affinity purified from pooled serum
Dilution Range: WB 1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Casr
Gene ID: 24247
Uniprot ID: CASR_RAT
Immunogen Region: N-Term
Immunogen: Synthetic peptide from the N-terminus region of the rat calcium sensing receptor.
Function G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation.
Protein Name Extracellular Calcium-Sensing Receptor
Casr
Parathyroid Cell Calcium-Sensing Receptor
Pcar1
Rakcar
Database Links Reactome: R-RNO-416476
Reactome: -RNO-418594
Reactome: -RNO-420499
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Extracellular Calcium-Sensing Receptor antibody
Anti-Casr antibody
Anti-Parathyroid Cell Calcium-Sensing Receptor antibody
Anti-Pcar1 antibody
Anti-Rakcar antibody
Anti-Casr antibody
Anti-Gprc2a antibody
Anti-Pcar1 antibody

Information sourced from Uniprot.org

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