| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CASQ2 |
| Gene ID: | 845 |
| Uniprot ID: | CASQ2_HUMAN |
| Immunogen Region: | 20-399 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-399 of human CASQ2 (NP_001223.2). |
| Immunogen Sequence: | EEGLNFPTYDGKDRVVSLSE KNFKQVLKKYDLLCLYYHEP VSSDKVTQKQFQLKEIVLEL VAQVLEHKAIGFVMVDAKKE AKLAKKLGFDEEGSLYILKG DRTIEFDGEFAADVLVEFLL DLIEDPVEIISSKLEVQAFE RIEDYIKLIGFFKSEDSEYY KAFEEAAEHFQPYIKFFATF DKGVAKKLSLKMNEVDFYEP FMDEPIAIPNKPYTEEELVE FVKEHQRPTLRRLRPEEMF |
| Post Translational Modifications | Phosphorylation in the C-terminus, probably by CK2, moderately increases calcium buffering capacity. N-glycosylated. |
| Function | Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2.this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. |
| Protein Name | Calsequestrin-2 Calsequestrin - Cardiac Muscle Isoform |
| Database Links | Reactome: R-HSA-2672351 Reactome: R-HSA-5578775 |
| Cellular Localisation | Sarcoplasmic Reticulum Lumen This Isoform Of Calsequestrin Occurs In The Sarcoplasmic Reticulum's Terminal Cisternae Luminal Spaces Of Cardiac And Slow Skeletal Muscle Cells |
| Alternative Antibody Names | Anti-Calsequestrin-2 antibody Anti-Calsequestrin - Cardiac Muscle Isoform antibody Anti-CASQ2 antibody |
Information sourced from Uniprot.org