| Host: |
Mouse |
| Applications: |
IHC-F/IHC-P/WB |
| Reactivity: |
Human/Swine |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Cardiotin is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
SR-2 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgM |
| Formulation: |
PBS with 0.09% sodium azide |
| Dilution Range: |
IHC-F 1:25-1:100IHC-P 1:25-1:100WB 1:50-1:500 |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Immunogen: |
100 kDa cardiotin subunit |
| Background | Cardiotin is a high molecular weight protein complex (300 kDa) located in the mitochondria of cardiomyocytes and skeletal muscle. The cardiotin structure exists of subunits of 60 kDa and 100 kDa, probably in a tetrameric configuRation. Both subunits contain the same amino-terminal 14 amino-acid sequence, showing high homology to Human skeletal muscle Alpha-actinin. During cardiac contractile dysfunction and myocard cell differentiation, the cardiotin distribution is affected. Compared to other structural proteins, cardiotin is one of the first to respond to insults (ischemia, fibrillation) that influence the functional status of cardiomyocytes. SR-2 reacts with cardiomyocytes, skeletal muscle, stromal and epithelial cells as well in vivo as in vitro. |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
