Anti-Cardiac Troponin I (TNNI3) antibody [SRM14456] (STJ11109186)

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STJ11109186
€142.20 - €625.80
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Host: Rabbit
Applications: WB/IF-P/ELISA
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : SRM14456
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity purification
Dilution Range: WB, 1:1000-1:5000
IF-P, 1:100-1:500
ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TNNI3
Gene ID: 7137
Uniprot ID: TNNI3_HUMAN
Immunogen: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Post Translational Modifications Phosphorylated at Ser-42 and Ser-44 by PRKCE.phosphorylation increases myocardium contractile dysfunction. Phosphorylated at Ser-23 and Ser-24 by PRKD1.phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-31. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).
Function Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Protein Name Troponin I - Cardiac Muscle
Cardiac Troponin I
Database Links Reactome: R-HSA-390522
Reactome: R-HSA-5578775
Cellular Localisation
Alternative Antibody Names Anti-Troponin I - Cardiac Muscle antibody
Anti-Cardiac Troponin I antibody
Anti-TNNI3 antibody
Anti-TNNC1 antibody

Information sourced from Uniprot.org

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