| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CAPNS1 |
| Gene ID: | 826 |
| Uniprot ID: | CPNS1_HUMAN |
| Immunogen Region: | 69-268 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 69-268 of human Calpain small subunit 1 (NP_001740.1). |
| Immunogen Sequence: | ISEAAAQYNPEPPPPRTHYS NIEANESEEVRQFRRLFAQL AGDDMEVSATELMNILNKVV TRHPDLKTDGFGIDTCRSMV AVMDSDTTGKLGFEEFKYLW NNIKRWQAIYKQFDTDRSGT ICSSELPGAFEAAGFHLNEH LYNMIIRRYSDESGNMDFDN FISCLVRLDAMFRAFKSLDK DGTGQIQVNIQEWLQLTMYS |
| Function | Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development. |
| Protein Name | Calpain Small Subunit 1Css1Calcium-Activated Neutral Proteinase Small SubunitCanp Small SubunitCalcium-Dependent Protease Small SubunitCdpsCalcium-Dependent Protease Small Subunit 1Calpain Regulatory Subunit |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-6809371Reactome: R-HSA-8862803 |
| Cellular Localisation | CytoplasmCell MembraneTranslocates To The Plasma Membrane Upon Calcium Binding |
| Alternative Antibody Names | Anti-Calpain Small Subunit 1 antibodyAnti-Css1 antibodyAnti-Calcium-Activated Neutral Proteinase Small Subunit antibodyAnti-Canp Small Subunit antibodyAnti-Calcium-Dependent Protease Small Subunit antibodyAnti-Cdps antibodyAnti-Calcium-Dependent Protease Small Subunit 1 antibodyAnti-Calpain Regulatory Subunit antibodyAnti-CAPNS1 antibodyAnti-CAPN4 antibodyAnti-CAPNS antibody |
Information sourced from Uniprot.org