| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CAPN2 |
| Gene ID: | 824 |
| Uniprot ID: | CAN2_HUMAN |
| Immunogen Region: | 350-680 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-680 of human Calpain 2 (NP_001739.2). |
| Immunogen Sequence: | SDTYKKWKLTKMDGNWRRGS TAGGCRNYPNTFWMNPQYLI KLEEEDEDEEDGESGCTFLV GLIQKHRRRQRKMGEDMHTI GFGIYEVPEELSGQTNIHLS KNFFLTNRARERSDTFINLR EVLNRFKLPPGEYILVPSTF EPNKDGDFCIRVFSEKKADY QAVDDEIEANLEEFDISEDD IDDGFRRLFAQLAGEDAEIS AFELQTILRRVLAKRQDIKS DGFSIETCKIMVDMLDSDG |
| Tissue Specificity | Ubiquitous. |
| Function | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. |
| Protein Name | Calpain-2 Catalytic SubunitCalcium-Activated Neutral Proteinase 2Canp 2Calpain M-TypeCalpain Large Polypeptide L2Calpain-2 Large SubunitMillimolar-CalpainM-Calpain |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-8862803 |
| Cellular Localisation | CytoplasmCell MembraneTranslocates To The Plasma Membrane Upon Ca(2+) Binding |
| Alternative Antibody Names | Anti-Calpain-2 Catalytic Subunit antibodyAnti-Calcium-Activated Neutral Proteinase 2 antibodyAnti-Canp 2 antibodyAnti-Calpain M-Type antibodyAnti-Calpain Large Polypeptide L2 antibodyAnti-Calpain-2 Large Subunit antibodyAnti-Millimolar-Calpain antibodyAnti-M-Calpain antibodyAnti-CAPN2 antibodyAnti-CANPL2 antibody |
Information sourced from Uniprot.org