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Anti-CANX antibody (550 aa C-Term) {DyLight®488} (STJ140256)

Anti-CANX antibody conjugated to DyLight@488 at 1/2,000 dilution using cell lysates at 40 µg per lane
Immunofluorescence – anti-CANX antibody conjugated with DyLight®488 using MCR cells; cells were fixed with methanol and anti-CANX at 1/250

Anti-CANX antibody (550 aa C-Term) {DyLight®488} (STJ140256)

SKU:

STJ140256

£141.50 - £425.50

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Goat
Applications:	WB/IHC-F/IF
Reactivity:	Human/Rat/Mouse/Canine/Monkey
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-CANX (550 aa C-Term) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	DyLight®488
Isotype:	IgG
Formulation:	PBS, 20% Glycerol, 0.05% ProClin® and 0.05% Sodium Azide.
Purification:	Epitope affinity purified
Concentration:	2 mg/ml
Dilution Range:	WB 1:500-1:5000 IF 1:50-1:500 IHC-F 1:200-1:1000
Storage Instruction:	For continuous use, store at 2-8 C for one-two days. For extended storage, store in-20 C freezer. Working dilution samples should be discarded if not used within 12 hours.

Gene Symbol:	CANX
Gene ID:	821
Uniprot ID:	CALX_HUMAN
Immunogen Region:	550 aa C-Term
Specificity:	Detects a band of 90 kDa by Western blot whole cell lysates.
Immunogen:	Purified recombinant peptide within residues 550 aa to the C-terminus of human CANX produced in E. coli.

Function	Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
Protein Name	Calnexin Ip90 Major Histocompatibility Complex Class I Antigen-Binding Protein P88 P90
Database Links	Reactome: R-HSA-168316 Reactome: R-HSA-2132295 Reactome: R-HSA-8984722 Reactome: R-HSA-901042 Reactome: R-HSA-9020956 Reactome: R-HSA-9683686 Reactome: R-HSA-9694548 Reactome: R-HSA-983170
Cellular Localisation	Endoplasmic Reticulum Membrane Single-Pass Type I Membrane Protein Endoplasmic Reticulum Melanosome Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv The Palmitoylated Form Preferentially Localizes To The Perinuclear Rough Er
Alternative Antibody Names	Anti-Calnexin antibody Anti-Ip90 antibody Anti-Major Histocompatibility Complex Class I Antigen-Binding Protein P88 antibody Anti-P90 antibody Anti-CANX antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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