Anti-CAMKK1 antibody (399-520) (STJ119127)

Name: Anti-CAMKK1 antibody (399-520) (STJ119127)
SKU: STJ119127
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ119127

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Short Description	Rabbit polyclonal CAMKK1 (399-520) antibody for use in WB, IHC-P and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/ELISA
Host	Rabbit
Reactivity	Human/Mouse
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	CAMKK1
Gene ID	84254
Uniprot ID	KKCC1_HUMAN
Immunogen Region	399-520
Immunogen Sequence	LHRKIKNEPVVFPEEPEISE ELKDLILKMLDKNPETRIGV PDIKLHPWVTKNGEEPLPSE EEHCSVVEVTEEEVKNSVRL IPSWTTVILVKSMLRKRSFG NPFEPQARREERSMSAPGNL LV
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 399-520 of human CAMKK1 (NP_757344.2).

Post Translational Modifications	Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4.
Function	Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.
Protein Name	Calcium/Calmodulin-Dependent Protein Kinase Kinase 1 Cam-Kk 1 Cam-Kinase Kinase 1 Camkk 1 Cam-Kinase Iv Kinase Calcium/Calmodulin-Dependent Protein Kinase Kinase Alpha Cam-Kk Alpha Cam-Kinase Kinase Alpha Camkk Alpha
Database Links	Reactome: R-HSA-111932 Reactome: R-HSA-442729 Reactome: R-HSA-9619229
Cellular Localisation	Cytoplasm Nucleus
Alternative Antibody Names	Anti-Calcium/Calmodulin-Dependent Protein Kinase Kinase 1 antibody Anti-Cam-Kk 1 antibody Anti-Cam-Kinase Kinase 1 antibody Anti-Camkk 1 antibody Anti-Cam-Kinase Iv Kinase antibody Anti-Calcium/Calmodulin-Dependent Protein Kinase Kinase Alpha antibody Anti-Cam-Kk Alpha antibody Anti-Cam-Kinase Kinase Alpha antibody Anti-Camkk Alpha antibody Anti-CAMKK1 antibody Anti-CAMKKA antibody

Information sourced from Uniprot.org