| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CALHM1 (202-346) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CALHM1 |
| Gene ID: |
255022 |
| Uniprot ID: |
CAHM1_HUMAN |
| Immunogen Region: |
202-346 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 202-346 of human CALHM1 (NP_001001412.3). |
| Immunogen Sequence: |
VRSVRPCFTQAAFLKSKYWS HYIDIERKLFDETCTEHAKA FAKVCIQQFFEAMNHDLELG HTHGTLATAPASAAAPTTPD GAEEEREKLRGITDQGTMNR LLTSWHKCKPPLRLGQEEPP LMGNGWAGGGPRPPRKEVAT YFSKV |
| Tissue Specificity | Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells. Specifically expressed in circumvallate taste bud cells. |
| Function | Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Together with CALHM3, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs). Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner. |
| Protein Name | Calcium Homeostasis Modulator Protein 1Protein Fam26c |
| Database Links | Reactome: R-HSA-9717207Reactome: R-HSA-9730628 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneBasolateral Cell MembraneColocalizes With Hspa5 At The Endoplasmic ReticulumLocalizes To The Basolateral Membrane Of Epithelial Cells Including Taste Cells |
| Alternative Antibody Names | Anti-Calcium Homeostasis Modulator Protein 1 antibodyAnti-Protein Fam26c antibodyAnti-CALHM1 antibodyAnti-FAM26C antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
