| Host: |
Rabbit |
| Applications: |
WB/IHC-P/ELISA |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CALHM1 |
| Gene ID: |
255022 |
| Uniprot ID: |
CAHM1_HUMAN |
| Immunogen Region: |
202-346 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 202-346 of human CALHM1 (NP_001001412.3). |
| Immunogen Sequence: |
VRSVRPCFTQAAFLKSKYWS HYIDIERKLFDETCTEHAKA FAKVCIQQFFEAMNHDLELG HTHGTLATAPASAAAPTTPD GAEEEREKLRGITDQGTMNR LLTSWHKCKPPLRLGQEEPP LMGNGWAGGGPRPPRKEVAT YFSKV |
| Tissue Specificity | Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells. Specifically expressed in circumvallate taste bud cells. |
| Post Translational Modifications | N-glycosylated. Assembly with CALHM3 is associated with N-glycan remodeling and formation of hybrid complex- and high mannose-type glycochains. This N-glycan processing regulates channel trafficking and gating kinetics. Palmitoylated by ZDHHC3, ZDHHC20 and possibly ZDHHC7. Palmitoylation regulates voltage-dependent gating of the channel by shifting it toward more depolarized potentials. |
| Function | Pore-forming subunit of gustatory voltage-gated ion channels required for sensory perception of sweet, bitter and umami tastes. With CALHM3 forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to membrane depolarization and low extracellular Ca(2+) concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of small ions including Ca(2+), Na(+), K(+) and Cl(-), as well as larger ions such as ATP(4-). Mediates Ca(2+) influx and downstream activation of the ERK1 and ERK2 cascade in neurons. Triggers endoplasmic reticulum stress by reducing the Ca(2+) content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+)-dependent manner. |
| Protein Name | Calcium Homeostasis Modulator Protein 1Protein Fam26c |
| Database Links | Reactome: R-HSA-9717207Reactome: R-HSA-9730628 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneBasolateral Cell MembraneColocalizes With Hspa5 At The Endoplasmic ReticulumLocalizes To The Basolateral Membrane Of Epithelial Cells Including Taste Cells |
| Alternative Antibody Names | Anti-Calcium Homeostasis Modulator Protein 1 antibodyAnti-Protein Fam26c antibodyAnti-CALHM1 antibodyAnti-FAM26C antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
