| Host: | Rabbit |
| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CACNG2 |
| Gene ID: | 10369 |
| Uniprot ID: | CCG2_HUMAN |
| Immunogen Region: | 204-323 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 204-323 of human CACNG2 (NP_006069.1). |
| Immunogen Sequence: | RHKQLRATARATDYLQASAI TRIPSYRYRYQRRSRSSSRS TEPSHSRDASPVGIKGFNTL PSTEISMYTLSRDPLKAATT PTATYNSDRDNSFLQVHNCI QKENKDSLHSNTANRRTTPV |
| Tissue Specificity | Brain. |
| Post Translational Modifications | Phosphorylation of Thr-321 impairs interaction with DLG1 and DLG4. |
| Function | Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. |
| Protein Name | Voltage-Dependent Calcium Channel Gamma-2 Subunit Neuronal Voltage-Gated Calcium Channel Gamma-2 Subunit Transmembrane Ampar Regulatory Protein Gamma-2 Tarp Gamma-2 |
| Database Links | Reactome: R-HSA-112308 Reactome: R-HSA-399719 Reactome: R-HSA-5682910 |
| Cellular Localisation | Membrane Multi-Pass Membrane Protein Synapse Synaptosome |
| Alternative Antibody Names | Anti-Voltage-Dependent Calcium Channel Gamma-2 Subunit antibody Anti-Neuronal Voltage-Gated Calcium Channel Gamma-2 Subunit antibody Anti-Transmembrane Ampar Regulatory Protein Gamma-2 antibody Anti-Tarp Gamma-2 antibody Anti-CACNG2 antibody |
Information sourced from Uniprot.org