| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CACNB1 (429-598) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CACNB1 |
| Gene ID: |
782 |
| Uniprot ID: |
CACB1_HUMAN |
| Immunogen Region: |
429-598 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 429-598 of human CACNB1 (NP_000714.3). |
| Immunogen Sequence: |
ATAALAASPAPVSNLQGPYL ASGDQPLERATGEHASMHEY PGELGQPPGLYPSSHPPGRA GTLRALSRQDTFDADTPGSR NSAYTELGDSCVDMETDPSE GPGLGDPAGGGTPPARQGSW EDEEEDYEEELTDNRNRGRN KARYCAEGGGPVLGRNKNEL EGWGRGVYIR |
| Tissue Specificity | Detected in heart ventricle (at protein level). Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle. |
| Function | Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit. |
| Protein Name | Voltage-Dependent L-Type Calcium Channel Subunit Beta-1Cab1Calcium Channel Voltage-Dependent Subunit Beta 1 |
| Database Links | Reactome: R-HSA-112308Reactome: R-HSA-419037Reactome: R-HSA-5576892Reactome: R-HSA-5576893 |
| Cellular Localisation | Cell MembraneSarcolemmaPeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Voltage-Dependent L-Type Calcium Channel Subunit Beta-1 antibodyAnti-Cab1 antibodyAnti-Calcium Channel Voltage-Dependent Subunit Beta 1 antibodyAnti-CACNB1 antibodyAnti-CACNLB1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
