Western blot analysis of extracts of HepG2 cells, using CACNB1 Antibody (STJ29963) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-CACNB1 antibody (429-598) (STJ29963)

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STJ29963
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CACNB1
Gene ID: 782
Uniprot ID: CACB1_HUMAN
Immunogen Region: 429-598
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 429-598 of human CACNB1 (NP_000714.3).
Immunogen Sequence: ATAALAASPAPVSNLQGPYL ASGDQPLERATGEHASMHEY PGELGQPPGLYPSSHPPGRA GTLRALSRQDTFDADTPGSR NSAYTELGDSCVDMETDPSE GPGLGDPAGGGTPPARQGSW EDEEEDYEEELTDNRNRGRN KARYCAEGGGPVLGRNKNEL EGWGRGVYIR
Tissue Specificity Detected in heart ventricle (at protein level). Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle.
Function Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit.
Protein Name Voltage-Dependent L-Type Calcium Channel Subunit Beta-1
Cab1
Calcium Channel Voltage-Dependent Subunit Beta 1
Database Links Reactome: R-HSA-112308
Reactome: R-HSA-419037
Reactome: R-HSA-5576892
Reactome: R-HSA-5576893
Cellular Localisation Cell Membrane
Sarcolemma
Peripheral Membrane Protein
Cytoplasmic Side
Alternative Antibody Names Anti-Voltage-Dependent L-Type Calcium Channel Subunit Beta-1 antibody
Anti-Cab1 antibody
Anti-Calcium Channel Voltage-Dependent Subunit Beta 1 antibody
Anti-CACNB1 antibody
Anti-CACNLB1 antibody

Information sourced from Uniprot.org

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