Anti-CACNA2D2 antibody (560-610 aa) (STJ13100831)

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STJ13100831-100
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Short Description :Rabbit polyclonal anti-CACNA2D2 (560-610 aa) for use in IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications:IHC/WB
Host:Rabbit
Reactivity:Human/Mouse/Rat
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Purification:IgG purified
Dilution Range:IHC, WB (confirmed by recombinant protein). A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Formulation:Lyophilised
Storage Instruction:Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol:CACNA2D2
Gene ID:9254
Uniprot ID:CA2D2_HUMAN
Immunogen:A synthetic peptide from aa region 560-610 of human CACNA2D2 conjugated to blue carrier protein was used as the antigen. The antigen shares 95% identity with the corresponding sequences in mouse and rat.
Immunogen Region:560-610 aa
Specificity:Specific for CACNA2D2.
Post Translational Modifications May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role.
Function The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.
Protein Name Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-2
Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-2 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-2 - Voltage-Dependent Calcium Channel Subunit Delta-2
Database Links Reactome: R-HSA-112308
Reactome: R-HSA-400042
Reactome: R-HSA-422356
Reactome: R-HSA-5576892
Reactome: R-HSA-5576893
Reactome: R-HSA-9662360
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Colocalizes With Cacna1a In Lipid Raft Fractions
Alternative Antibody Names Anti-Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-2 antibody
Anti-Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-2 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-2 - Voltage-Dependent Calcium Channel Subunit Delta-2 antibody
Anti-CACNA2D2 antibody
Anti-KIAA0558 antibody

Information sourced from Uniprot.org

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