• Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-CACNA1G antibody (360-440 aa) (STJ191633)

SKU:
STJ191633

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Voltage-dependent T-type calcium channel subunit alpha-1G (360-440 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC-P 1:50-300
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CACNA1G
Gene ID: 8913
Uniprot ID: CAC1G_HUMAN
Immunogen Region: 360-440 aa
Specificity: CAC1G Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from the human protein at the amino acid range 360-440
Post Translational Modifications In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.
Function Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
Protein Name Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1g
Cav3.1c
Nbr13
Voltage-Gated Calcium Channel Subunit Alpha Cav3.1
Database Links Reactome: R-HSA-419037
Reactome: R-HSA-445355
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cytoplasm
Alternative Antibody Names Anti-Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1g antibody
Anti-Cav3.1c antibody
Anti-Nbr13 antibody
Anti-Voltage-Gated Calcium Channel Subunit Alpha Cav3.1 antibody
Anti-CACNA1G antibody
Anti-KIAA1123 antibody

Information sourced from Uniprot.org

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