| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CACNA1E (2014-2313) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CACNA1E |
| Gene ID: |
777 |
| Uniprot ID: |
CAC1E_HUMAN |
| Immunogen Region: |
2014-2313 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 2014-2313 of human CACNA1E (NP_001192222.1). |
| Immunogen Sequence: |
PSSMRRSFSTIRDKRSNSSW LEEFSMERSSENTYKSRRRS YHSSLRLSAHRLNSDSGHKS DTHRSGGRERGRSKERKHLL SPDVSRCNSEERGTQADWES PERRQSRSPSEGRSQTPNRQ GTGSLSESSIPSVSDTSTPR RSRRQLPPVPPKPRPLLSYS SLIRHAGSISPPADGSEEGS PLTSQALESNNACLTESSNS PHPQQSQHASPQRYISEPYL ALHEDSHASDCGEEETLTF |
| Tissue Specificity | Expressed in neuronal tissues and in kidney. |
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells. They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. |
| Protein Name | Voltage-Dependent R-Type Calcium Channel Subunit Alpha-1eBrain Calcium Channel IiBiiCalcium Channel - L Type - Alpha-1 Polypeptide - Isoform 6Voltage-Gated Calcium Channel Subunit Alpha Cav2.3 |
| Database Links | Reactome: R-HSA-112308Reactome: R-HSA-422356 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Voltage-Dependent R-Type Calcium Channel Subunit Alpha-1e antibodyAnti-Brain Calcium Channel Ii antibodyAnti-Bii antibodyAnti-Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 6 antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha Cav2.3 antibodyAnti-CACNA1E antibodyAnti-CACH6 antibodyAnti-CACNL1A6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
