| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CACNA1E |
| Gene ID: | 777 |
| Uniprot ID: | CAC1E_HUMAN |
| Immunogen Region: | 2014-2313 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 2014-2313 of human CACNA1E (NP_001192222.1). |
| Immunogen Sequence: | PSSMRRSFSTIRDKRSNSSW LEEFSMERSSENTYKSRRRS YHSSLRLSAHRLNSDSGHKS DTHRSGGRERGRSKERKHLL SPDVSRCNSEERGTQADWES PERRQSRSPSEGRSQTPNRQ GTGSLSESSIPSVSDTSTPR RSRRQLPPVPPKPRPLLSYS SLIRHAGSISPPADGSEEGS PLTSQALESNNACLTESSNS PHPQQSQHASPQRYISEPYL ALHEDSHASDCGEEETLTF |
| Tissue Specificity | Expressed in neuronal tissues and in kidney. |
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells. They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. Isoform 3: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells. They are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. |
| Protein Name | Voltage-Dependent R-Type Calcium Channel Subunit Alpha-1e Brain Calcium Channel Ii Bii Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 6 Voltage-Gated Calcium Channel Subunit Alpha Cav2.3 |
| Database Links | Reactome: R-HSA-112308 Reactome: R-HSA-422356 |
| Cellular Localisation | Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Voltage-Dependent R-Type Calcium Channel Subunit Alpha-1e antibody Anti-Brain Calcium Channel Ii antibody Anti-Bii antibody Anti-Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 6 antibody Anti-Voltage-Gated Calcium Channel Subunit Alpha Cav2.3 antibody Anti-CACNA1E antibody Anti-CACH6 antibody Anti-CACNL1A6 antibody |
Information sourced from Uniprot.org